first day working

I woke up early in the morning and be at the working place one hour earlier. When I reached there, I couldn't get the entrance because the staff entrance was at the side door. I couldn't find my product as well. So weird right? It took me more than an hour for searching and asking. Ended up with nothing. They said this is a new product they don't have the stock yet. I was shocked when i was being told so. Thus, my supervisor asked me to do sampling only. Surprisingly, those kids were very scary, kept on asking for sample. Ohya, i forgot to mention my product is oat quaker. I like the taste =). The time past quite fast. It finally ended. Suddenly, a promoter came and asked me where am i staying. I said cyberjaya cause studying in mmu. Then she told me there's another promoter studying there as well. So I met that guy. Then he offered me for a ride. How luckily i was. In the car, we chat a lot about being the real 'hero'. He was right. Most people who are 'hero' in schooling time will be terrible in their working time. Of course we can't say it's 100%. It was true. I got so many prizes from different stages, yet i am now getting nothing. Wake up Vincent! Don't let others to think that you are a 'hero' for schooling. Be a 'hero' in future!

thanks for the "good"

live every moment.
grab every opportunity.
have fun in everything you do.
friends you've met will be friends forever.
experience each and single incident with an open heart.

Today i went for a product training.
It was not as good as i thought.
However there was something impressed me.
First of all, the whole training was being delayed terribly.
Then I was not given any info at all, as they thought i was one of those experienced.
There were 2 newbies.
one of them is me.
the very beginning, I was asked to prepare the drink.
only 2 were chosen.
i was "lucky" to be chosen. i mean not a bad thing.(at least ppl still realize the existence of mine).
well, nothing special besides felt being "existed".
next, we were all divided into pair.
again i was in the first pair.
i was like huh? How's everything supposed to be?
Most of them have already known what to be done due to their experiences.
After my first "test" few of them said i was good.
They started to ask what product did i promote previously.
I answered this is my first time, and i have never done this before.
They got surprised they told me that they thought i have been working there quite some time just different product.
That really giving a great confident.
Ever since 2005 no one actually feedback to me so.
Many of them either newbie or experienced tried to memorize and they couldn't get it.
I actually didn't prepare anything at all yet i could handle it.
nice try for me.
hope every step in sooner would be better.

arrr my keyboard bitten by rat?

when i woke up in the morning, I shouted " oooh no my keyboard's gone." being destroyed by the rat. it's very pity right? so at this moment i won't be available to reply as convenient as before. So my advise to u all is never put a mouse on ur keyboard. I really never thought of this incident will happen. A msg to myself this is not a tragedy but a weird and funny. cheers

basic training

the basic training was actually a normal training. It was like a normal class, nothing special. There were quite a number of people who were just from secondary school. They were great. If were to ask me comment it, I would like to say nothing special. It's a good company i think and of course i wish it to be. There were few awards to be won. I wish i will be one of them. Through this training, i noticed it's really important to know english well. There were a person who couldn't speak well. It was really a tough one for her. However, that job was just to earn extra money. I wish i would be better soon so that can earn more. haha. my aim my goal. Recently, there is a friend of mine who suddenly disappear herself. I really don't like this feeling. When sometimes when bored only find me and i will reply as soon. When i just want to have a normal chat, yet she doesn't even reply. Should I just forget her?

a useless person?

Tomorrow will be an interview day. Need to get part time job already. During the last time i went back my hometown I found that I am much more useless than I thought. One thing that I am really happy about is my brothers, they are really much more matured and better than me. What a shameful being the eldest brother in the home yet the most useless. What causes me to be like that? Excuses? I used to telling myself that I can't let go the person who caused me to start this blog. However that should be an excuse. How am i supposed to get out of it? Stop giving excuse for it? It's easy by spoken but hard to be done. Why would I started to lose everything after that incident? A message to myself please say no to excuse and please say yes to success.

happy melaka trip

to him :
thanks brother for giving me such a nice memory trip. I feel much better. I will choose to be a better way. I really felt very happy during the whole trip. I really very long time didn't have this kind of feeling. I wish in future i will have more friends like you. haha.. don't angry later ya.. lol.. you too must take care =)

to her:
i miss you so much. thanks for understanding me. Situation told me that i am totally out of this. Under no circumstances will i hurt you, so i choose to remain as friend or better as good friend.

parkinson disease affected by genes (general knowledge)

Parkinson is a disease which will cause a human being unable to move due the problem in sending the signal from the organ to the brain. In general, Parkinson disease is being divided by two groups which are early-onset and late-onset. The late-onset will attack those people who are at the age of 50years old or older. On the other hand, the early-onset will be referring to the younger generation which is before 50 years old. Researchers have found out that genes are associated with Parkinson disease. The main three genes are GBA, SNCAIP, and UCHL1.

The official name for GBA is “glucosidase, beta; acid (includes glucosylceramidase).” The GBA functions as enzyme producer. It produces the enzyme of beta-glucocerebrosidase. This enzyme is active in lysosomes which are being used to break down the toxic substances, digest bacteria in the cell, and also recycle the worn-out cell components. Besides it also helps to break down glucocerebroside into a glucose and ceramide. However in growing evidence suggests that GBA mutation and Parkinson disease are associated. Researchers have found that people who have Gaucher disease and GBA carriers will have higher risk in getting Parkinson disease. In general, Parkinson disease occurs when the nerve cells in human being are getting lesser which will produce dopamine. Dopamine is a signal which is being transmitted from brain to the organs and vice versa. Researchers believe that GBA mutations may contribute in the faulty of breaking down the toxic substances in nerve cells by impairing the function of lysosomes. It may also enhace the formation of abnormal protein deposits. In that case, the toxic substances and protein deposits could kill the dopamine which is the nerve cells producers. If the nerve cells are insufficient enough, it will lead to difficulties in moving and balancing.

Another genes which have a link to Parkinson disease is SNCAIP genes. The general name for SNCAIP is “synuclein, alpha interacting protein (synphilin).” This gene functions as producing synphilin-1 protein. These proteins are usually located in specialized structures which are in presynaptic terminals at the tips of nerve cells. In nerve cells, synphilin-1 and synphilin-1A will interact with another protein which is alpha-synuclein. However there are not many Parkinson diseases which are caused by SNCAIP genes. For this mutation will lead to a change in one of the building blocks used to produce synphilin-1. Some studies believe that altered synphilin-1 proteins cluster together, which could disturb normal cell activities which is including the nerve cells. Synphilin-1 and alpha-synuclein are components a part of Lewy bodies. Lewy bodies in a region of brain called substantia nigra, which controls balancing and moving. If problems occur in Lewy bodies to a person, he or she will also suffer from Parkinson disease.

The third gene which associates with Parkinson disease is UCHL1. UCHL1 is generally known as “ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase).” The UCHL1 is a gene which produces ubiquitin carboxyl-terminal esterase L1 enzyme. This enzyme can usually being found in nerve cells throughout the brain. It will help to degrade those unwanted proteins. The UCHL1 appears to reduce the risk of getting Parkinson disease especially in young adults. This will happen when there is a change in one of the blocks of acid amino which is used to produce UCHL1 enzyme. This will usually happen in Chinese and Japanese. However, it is lesser possibilities for European populations to get this problem. When the problem occurs it will reduce the ligase activity of the UCHL1 enzyme but has little effect on hydrolase activity. This will indirectly increase the risk of having Parkinson disease. There has been reported in two siblings with this disease. It was being explained that the mutation replaces the amino acid isoleucine with the amino acid methionine in UCHL1 enzyme. The mutation will decrease the hydrolase activity. It that way it may disrupt the ubiquitin-proteasome system. Instead of degrading, those unwanted proteins may accumulate to toxic levels that impair or kill nerve cells in the brain. It has been identified in only a single family.

In a nut shell, we can see that Parkinson disease which associated by UCHL1 genes take part in early-onset categories. The problem is due to the mutation of the genes are not very completed. If were to look at the first three problems we could clearly see that they affect more by protein extraction. However, most people who are having the age which is more than fifty which is in the late-onset category will have a higher possibility in getting this disease. From the three examples, we could see that genetic does not directly affect on the Parkinson disease. We can only see that the enzyme which produced by the genes affect more.

knowledge from:

http://ghr.nlm.nih.gov/condition=parkinsondisease

i miss you

i miss you..
i really miss you..
i miss you soooo much..
i miss those days we being together..
i hate those days without you..
so where's the vincent that used to be?
please come back to me..
I thought the hard time has past..
but it still floating around..
i can do nothing other than hoping..
and be more wise..
be stronger..

hard time passed?

the hard rock is broken?
well i just gone through many of the hard times.
i have no idea whether I am getting used to those or in a turning point which turn to another condition.
well, i hope everything (bad(S)) has already ended.
I wish to reconstruct everything.
trying not to look back.
let the past to be the past.
look on the future with hope.
I should appreciate with everything I am having.
though i am really angry to those who have gossiped and brought me down.
I will not think of taking any revenge.
I will not continue stepping into the trap as well.
I will not tell others how I was being gossiped and brought down.
I will not allow these to occur in my life.